(+)-Aeroplysinin-1 (Synonyms: NSC 170364) |
| Catalog No.GC18516 |
(+)-Aeroplysinin-1((+)-Aeroplysinin-1)은 해양 해면에서 분리된 2차 대사산물로 그람 양성균에 강력한 항생 효과를 나타내며 HIV-1(IC50\u003d14.6μM)에 항바이러스 활성을 나타냅니다.
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Cas No.: 28656-91-9
Sample solution is provided at 25 µL, 10mM.
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(+)-Aeroplysinin-1 is a metabolite originally isolated from the marine sponge V. aerophoba with diverse biological activities. (+)-Aeroplysinin-1 (0.25-0.5 μM) induces cell death in MCF-7 and ZR-75-1 human breast cancer cells in a time- and concentration-dependent manner but has no effect on normal human fibroblasts at concentrations up to 5 μM. It also blocks EGF-induced endocytosis of the EGF receptor (EGFR) and EGF-dependent cell proliferation in MCF-7 cells. (+)-Aeroplysinin-1 inhibits bovine aortic endothelial (BAE) cell proliferation and cord formation in a Matrigel assay. It inhibits angiogenesis in a dose-dependent manner in a chick chorioallantoic membrane (CAM) assay when administered from 1.5 to 3 nmol per egg. (+)-Aeroplysinin-1 also has antibacterial activity against Gram-positive bacteria, including S. aureus, S. albus, and B. subtilis, but not Gram-negative bacteria and inhibits HIV-1 replication (IC50 = 14.6 μM) via inhibition of HIV-1 reverse transcriptase.
Review for (+)-Aeroplysinin-1
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
Review for (+)-Aeroplysinin-1
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