AMBMP hydrochloride |
| Catalog No.GC50323 |
AMBMP 염산염은 강력하고 세포 투과성인 Wnt 신호 활성화제입니다. BML-284는 700nM의 EC50으로 TCF 의존적 전사 활성을 유도합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2095432-75-8
Sample solution is provided at 25 µL, 10mM.
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Wnt canonical signaling activator. Also inhibits tubulin polymerization. Suppresses TLR2/4/5-induced inflammatory response in human monocytes. Inhibits cell proliferation and induces cell cycle arrest in MDA-MB-231 breast cancer cells. Also decreases embryo to blastocyst development.
Liu et al (2005) A small-molecule agonist of the Wnt signaling pathway. Angew.Chem.Int.Ed.Engl. 44 1987 PMID:15724259 |Wang et al (2016) 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine is an anti-inflammatory TLR-2, -4 and -5 response mediator in human monocytes. Inflamm.Res. 65 61 PMID:26613980 |Fukuda et al (2016) Tubulin is a molecular target of the Wnt-activating chemical probe. BMC Biochem. 17 9 PMID:27207629 |Denicol et al (2013) Canonical WNT signaling regulates development of bovine embryos to the blastocyst stage. Sci.Rep. 3 1266 PMID:23405280
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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