>>Signaling Pathways>> Immunology/Inflammation>> Pulmonary Diseases>>Arbutin-d4

Arbutin-d4 (Synonyms: β-Arbutin-d4)

Catalog No.GC48841

Arbutin-d4는 Arbutin으로 표시된 중수소입니다. 알부틴(β-알부틴)은 멜라닌 세포에서 티로시나제의 경쟁적 억제제이며 모노페놀라제에 대한 Kiapp 값은 1.42mM입니다. 디페놀라아제의 경우 0.9mM. 알부틴은 또한 탈색제로 사용됩니다. 알부틴은 월귤나무 식물인 Arctostaphylos uvaursi에서 분리된 천연 폴리페놀로 항산화, 항염 및 항종양 특성을 가지고 있습니다.

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Arbutin-d4 Chemical Structure

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US$512.00
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Sample solution is provided at 25 µL, 10mM.

Description of Arbutin-d4

Arbutin-d4 is intended for use as an internal standard for the quantification of arbutin by GC- or LC-MS. Arbutin is a glycosylated hydroquinone that has been found in Arctostaphylos plants and has diverse biological activities, including tyrosinase inhibitory, antioxidant, and anti-inflammatory properties.1,2 It inhibits human tyrosinase activity in crude tyrosinase solution isolated from human melanocytes (IC50s = 5.7 and 18.9 mM using L-tyrosine and L-DOPA as substrates, respectively) as well as in intact melanocytes (IC50 = 0.5 mM).3 Arbutin (50 μM) inhibits hemolysis induced by the free radical generator AAPH in sheep erythrocytes and inhibits AAPH-induced decreases in cell viability in cultured human skin fibroblasts when used at concentrations greater than 125 μM.2 In an LPS-induced rat model of acute lung injury, arbutin (50 mg/kg) prevents increases in IL-1β, IL-6, and TNF-α levels in lung tissue and serum.4 Formulations containing arbutin have been used in the treatment of hyperpigmentation disorders.

1.Seo, D.-H., Jung, J.-H., Lee, J.-E., et al.Biotechnological production of arbutins (α- and β-arbutins), skin-lightening agents, and their derivativesAppl. Microbiol. Biotechnol.95(6)1417-1425(2012) 2.Takebayashi, J., Ishii, R., Chen, J., et al.Reassessment of antioxidant activity of arbutin: Multifaceted evaluation using five antioxidant assay systemsFree Radic. Res.44(4)473-478(2010) 3.Maeda, K., and Fukuda, M.Arbutin: Mechanism of its depigmenting action in human melanocyte cultureJ. Pharmacol. Exp. Ther.276(2)765-769(1996) 4.Ye, J., Guan, M., Lu, Y., et al.Arbutin attenuates LPS-induced lung injury via Sirt1/ Nrf2/ NF-κBp65 pathwayPulm. Pharmacol. Ther.5453-59(2019)

Chemical Properties of Arbutin-d4

Cas No. SDF
Synonyms β-Arbutin-d4
Canonical SMILES OC[C@H]1O[C@@H](OC2=C([2H])C([2H])=C(O)C([2H])=C2[2H])[C@H](O)[C@@H](O)[C@@H]1O
Formula C12H12D4O7 M.Wt 276.3
Solubility Water: soluble Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Arbutin-d4

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1 mg 5 mg 10 mg
1 mM 3.6193 mL 18.0963 mL 36.1925 mL
5 mM 0.7239 mL 3.6193 mL 7.2385 mL
10 mM 0.3619 mL 1.8096 mL 3.6193 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 10 reference(s) in Google Scholar.)

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