>>AY254

AY254

Catalog No.GC72180

AY254은 AY77의 아날로그이다.

Products are for research use only. Not for human use. We do not sell to patients.

AY254 Chemical Structure

Cas No.: 2093408-03-6

Size 가격 재고 수량
1 mg
US$665.00
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Sample solution is provided at 25 µL, 10mM.

Description of AY254

AY254 is an analogue of AY77 . AY254 is ERK-biased PAR2 agonist with an EC50 of 2 nM. AY254 relieves cytokine-induced caspase 3/8 activation. AY254 also promotes scratch-wound healing and induced IL-8 secretion via PAR2-ERK1/2 signaling

References:
[1]. Jiang Y, et al. Biased Signaling by Agonists of Protease Activated Receptor 2. ACS Chem Biol. 2017 May 19;12(5):1217-1226.

Chemical Properties of AY254

Cas No. 2093408-03-6 SDF
Formula C30H49N9O6 M.Wt 631.77
Solubility Storage
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of AY254

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.5829 mL 7.9143 mL 15.8285 mL
5 mM 0.3166 mL 1.5829 mL 3.1657 mL
10 mM 0.1583 mL 0.7914 mL 1.5829 mL
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**When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / CoA (available online).

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In vivo Formulation Calculator (Clear solution) of AY254

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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리뷰

Review for AY254

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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