>>Signaling Pathways>> DNA Damage/DNA Repair>> CDK>>(-)-BAY-1251152

(-)-BAY-1251152 (Synonyms: (-)-BAY-1251152; (-)-VIP152)

Catalog No.GC32429

(-)-BAY-1251152((-)-BAY-1251152)는 회전(-)이 있는 BAY-1251152의 거울상 이성질체입니다. BAY-1251152는 강력하고 고도로 선택적인 PTEF/CDK9 억제제입니다.

Products are for research use only. Not for human use. We do not sell to patients.

(-)-BAY-1251152 Chemical Structure

Cas No.: 1610358-59-2

Size 가격 재고 수량
10mM (in 1mL DMSO)
US$295.00
재고 있음
2mg
US$147.00
재고 있음
5mg
US$331.00
재고 있음
10mg
US$506.00
재고 있음
50mg
US$1,517.00
재고 있음

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고객 리뷰

Based on customer reviews.

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(-)-BAY-1251152 is an enanthiomer of BAY-1251152 with rotation (-). BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor.

[1]. Luecking, et al. Identification of potent and highly selective PTEFb inhibitor BAY 1251152 for the treatment of cancer: from p.o. to i.v. application via scaffold hops. AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 984. doi:10.1158/1538-7445.AM2017-984

Chemical Properties

Cas No. 1610358-59-2 SDF
Synonyms (-)-BAY-1251152; (-)-VIP152
Canonical SMILES N=S(CC1=CC(NC2=NC=C(F)C(C3=CC=C(F)C=C3OC)=C2)=NC=C1)(C)=O.[Rotation(-)]
Formula C19H18F2N4O2S M.Wt 404.43
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.4726 mL 12.3631 mL 24.7262 mL
5 mM 0.4945 mL 2.4726 mL 4.9452 mL
10 mM 0.2473 mL 1.2363 mL 2.4726 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

리뷰

Review for (-)-BAY-1251152

Average Rating: 5 ★★★★★ (Based on Reviews and 23 reference(s) in Google Scholar.)

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