>>Signaling Pathways>> Ox Stress Reagents>> Antioxidants>>Biliverdin (hydrochloride)

Biliverdin (hydrochloride)

Catalog No.GC42932

빌리베르딘(염산염)은 헴의 분해에 의해 형성된 테트라피롤릭 수용성 화합물입니다.

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Biliverdin (hydrochloride) Chemical Structure

Cas No.: 856699-18-8

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10mg
US$46.00
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50mg
US$172.00
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100mg
US$298.00
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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Description of Biliverdin (hydrochloride)

Biliverdin is a green bile pigment produced from the oxidation of heme in a reaction catalyzed by heme oxygenase and is further reduced to bilirubin by biliverdin reductase.[1][2] Biliverdin regulates the cellular heme degradation process by inhibiting substrates from binding to the catalytic site of heme oxygenase. Bile pigments such as biliverdin are known to possess anti-mutagenic and antioxidant properties.[3][4]

Reference:
[1]. Liu, Y., Moënne-Loccoz, P., Loehr, T.M., et al. Heme oxygenase-1, intermediates in verdoheme formation and the requirement for reduction equivalents. The Journal of Biological Chemisty 272, 6909-6917 (1997).
[2]. Maines, M.D. The heme oxygenase system: A regulator of second messenger gases. Annu. Rev. Pharmacol. Toxicol. 37, 517-554 (1997).
[3]. Bulmer, A.C., Ried, K., Blanchfield, J.T., et al. The anti-mutagenic properties of bile pigments. Mutation Research 658(1-2), 28-41 (2008).
[4]. Mölzer, C., Huber, H., Steyrer, A., et al. In vitro antioxidant capacity and antigenotoxic properties of protoporphyrin and structurally related tetrapyrroles. Free Rad.Res. 46(11), 1369-1377 (2012).

Chemical Properties of Biliverdin (hydrochloride)

Cas No. 856699-18-8 SDF
Chemical Name 3,18-diethenyl-1,19,22,24-tetrahydro-2,7,13,17-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid, monohydrochloride
Canonical SMILES OC(CCC1=C(/C=C2C(CCC(O)=O)=C(C)C(/C=C3NC(C(C=C)=C\3C)=O)=N/2)NC(/C=C4NC(C(C)=C\4C=C)=O)=C1C)=O.Cl
Formula C33H34N4O6•HCl M.Wt 619.1
Solubility 20mg/mL in DMSO, 20mg/mL in DMF Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Biliverdin (hydrochloride)

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1 mg 5 mg 10 mg
1 mM 1.6152 mL 8.0762 mL 16.1525 mL
5 mM 0.323 mL 1.6152 mL 3.2305 mL
10 mM 0.1615 mL 0.8076 mL 1.6152 mL
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In vivo Formulation Calculator (Clear solution) of Biliverdin (hydrochloride)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Review for Biliverdin (hydrochloride)

Average Rating: 5 ★★★★★ (Based on Reviews and 22 reference(s) in Google Scholar.)

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