>>Signaling Pathways>> Others>> Fluorescent Probes>>(+)-Biotin 4-Amidobenzoic Acid (sodium salt)

(+)-Biotin 4-Amidobenzoic Acid (sodium salt) (Synonyms: (+)-Biotin PABA, N-Biotinyl-4-aminobenzoic Acid)

Catalog No.GC45258

(+)-Biotin 4-amidobenzoic acid is a substrate of biotinidase, which cleaves biotin amide to give biotin in vivo.

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(+)-Biotin 4-Amidobenzoic Acid (sodium salt) Chemical Structure

Cas No.: 102418-74-6

Size 가격 재고 수량
5mg
US$43.00
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10mg
US$69.00
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25mg
US$150.00
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50mg
US$214.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(+)-Biotin 4-amidobenzoic acid is a substrate of biotinidase, which cleaves biotin amide to give biotin in vivo. Biotin is an essential coenzyme for certain carboxylases and is used to modify histones and regulate gene transcription. Biotinidase has key roles in intestinal absorption of biotin, the transport of biotin in plasma, and in the regulation of histone biotinylation. (+)-Biotin 4-amidobenzoic acid is hydrolyzed by biotinidase to release 4-aminobenzoic acid (PABA), which can be quantified by either fluorescent or colorimetric methods. This approach is used in biotinidase activity assays in newborn screening protocols to evaluate biotinidase deficiency.

Chemical Properties

Cas No. 102418-74-6 SDF
Synonyms (+)-Biotin PABA, N-Biotinyl-4-aminobenzoic Acid
Canonical SMILES [O-]C(C1=CC=C(NC(CCCC[C@@H]2SC[C@@]3([H])[C@]2([H])NC(N3)=O)=O)C=C1)=O.[Na+]
Formula C17H20N3O4S•Na M.Wt 385.4
Solubility DMSO: 1 mg/mL,PBS (pH 7.2): 2 mg/mL Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.5947 mL 12.9735 mL 25.9471 mL
5 mM 0.5189 mL 2.5947 mL 5.1894 mL
10 mM 0.2595 mL 1.2974 mL 2.5947 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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