In the field of mental health, advances in drug development and treatment methods continuously bring new hope to patients. Among them, chlorpromazine antagonists, as an important class of neuro pharmaceuticals, have played an irreplaceable role in treating psychosis and other related diseases since their inception. This article will delve into the pharmacological effects, clinical applications, and profound impacts of chlorpromazine antagonists on mental health treatment.

Ferrostatin-1 (Fer-1) is a potent inhibitor of ferroptosis, a type of iron-dependent cell death implicated in various kidney diseases, including hyperuricemic nephropathy (HN). HN is a metabolic disorder characterized by elevated uric acid levels, leading to renal fibrosis and tubular necrosis.

A Novel Therapeutic Agent for Rheumatoid Arthritis, Agomelatine (AOM) is a promising pharmacological agent that has shown significant therapeutic potential in combating rheumatoid arthritis (RA), a chronic autoimmune disease characterized by inflammation and joint destruction. Recent studies have revealed AOM's efficacy in inhibiting tumor necrosis factor-alpha (TNFα) -mediated inflammation, a crucial pathway involved in RA pathogenesis.

Cinacalcet an FDA approved drug which kills bacteria by destroying bacterial membrane as well as respiratory metabolism and is used to treat secondary hyperparathyroidism and parathyroid cancer. It can also kill bacteria by producing reactive oxygen species (ROS). It was revealed by Limited Proteolysis -Small molecule mapping (LiP-SMap) that cinacalcet inhibits biofilm formation by targeting IcaR. Cinacalcet can partially remove the biofilm of drug-resistant S. aureus in an animal model it was revealed by in vitro and in vivo experiments . These findings suggest that cinacalcet has antibacterial and antibiofilm capabilities.

A ubiquitous metabolite that participates in numerous physiological processes, including transsulfuration, polyamine biosynthesis, and transmethylation is the ademetionine also known as S-adenosyl-L-methionine (AdoMet), SAM or SAMe ( Glpbio ).

A macrolide antibiotic, tylosin is active against gram-positive aerobic bacteria and mycoplasmas throughout a wide range of conditions. It is authorized for the treatment of a number of infectious disorders in cattle and poultry, including mastitis, respiratory conditions, and farm animal dysentery.

Introduction: RSM-932A, also known as TCD- 717, is a ChoKα asset, which targets the mortal choline kinase nascence, an enzyme involved in increased lipid metabolism of cancer cells. RSM-932A appears to have an altogether new medium of inhibition and is synergistic with respect to both choline and ATP. RSM-932A have in vitro inhibitory exertion in the low nanomolar range.

Brent R. Stockwell, Ferroptosis의 저자인으로서 10주년을 기념하여 연구 진행에 대해 리뷰를 썼다. 이 리뷰는 높은 영향 지수66.85(2022)를 가진 '셀' 저널에 게재되었다. 국가 자연 과학 재단의 프로젝트와 입찰 금액은 매년 증가하고 있고 관련 연구 논문도 자주 CNS를 상회하고 있다!(그림 1)

The sodium salt of palmitic acid, sodium palmitate ( Hexadecanoic acid sodium salt, Palmitic acid sodium salt) , produced during the process of fatty acid synthesis present in fats and waxes. It is produced synthetically and driven by palm oil. Plays major role as an emulsifier.

이전 문제에서 약물 용해의 다양한 공식과 전략을 소개했습니다. 그 중에서 권장되지 않는 DMSO는 코솔벤트로서도 일정한 위치를 차지하지만 매우 논쟁적입니다. 이 FDA가 제한하는 용매는 널리 전파되고 있으며 매우 독성이 강합니다. 얼마나 독성이 강한지 우리는 실험에서 어떻게 사용할까요?오늘 우리는 셀과 동물 실험에서 "대중매" DMSO를 올바르게 사용하는 방법을 당신에게 밝힐 것입니다.