>>Signaling Pathways>> Ubiquitination/ Proteasome>> Autophagy>>C8 Ceramide (d18:1.8:0)

C8 Ceramide (d18:1.8:0) (Synonyms: N-octanoyl-D-erythro-Sphingosine)

Catalog No.GC43105

C8 세라마이드 (d18:1.8:0) (N-옥타노일-D-에리스로-스핑고신)은 자연적으로 존재하는 세라마이드의 세포내 투과성 아날로그입니다.

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C8 Ceramide (d18:1.8:0) Chemical Structure

Cas No.: 74713-59-0

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

C8 Ceramide (d18:1.8:0)은 자연적으로 발생하는 세라마이드의 세포내 침투 가능한 아날로그입니다. C2 ceramide과 달리, 세포 내에서 대사되어 천연 세라마이드를 생성하며 종종 세포 내 세라마이드 수준을 급격하게 증가시킵니다. 이러한 이유로 C8 ceramide (d18:1.8:0)으로 세포를 처리하는 것은 짧은 사슬의 ceramide 아날로그로 처리하는 것보다 보다 자연스러운 ceramide 상승 효과를 더 가깝게 모방할 수 있습니다. C8 Ceramide (d18:1.8:0)는 많은 다양한 생물학적 활동을 유발할 가능성이 있으며, 천연 세라마이드와 마찬가지로 인간 각질세포의 분화를 촉진하고 인간 백혈병세포 및 U937세포주에 대해 약점 프로그램을 유도합니다.[1] [3]

References:

[1]. Karasavvas, N., Erukulla, R.K., Bittman, R., et al. Stereospecific induction of apoptosis in U937 cells by N-octanoyl-sphingosine stereoisomers and N-octyl-sphingosine. The ceramide amide group is not required for apoptosis. Eur. J. Biochem. 236(2), 729-737 (1996).
[2]. Wakita, H., Tokura, Y., Yagi, H., et al. Keratinocyte differentiation is induced by cell-permeant ceramides and its proliferation is promoted by sphingosine. Archives of Dermatological Research 286, 350-354 (1994).
[3]. Geley, S., Hartmann, B.L., and Kofler, R. Ceramides induce a form of apoptosis in human acute lymphoblastic leukemia cells that is inhibited by Bcl-2, but not by CrmA. FEBS Letters 400, 15-18 (1997).

Chemical Properties

Cas No. 74713-59-0 SDF
Synonyms N-octanoyl-D-erythro-Sphingosine
Chemical Name N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-octanamide
Canonical SMILES CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC(CCCCCCC)=O)CO
Formula C26H51NO3 M.Wt 425.7
Solubility 20mg/mL in DMSO, 22mg/mL in DMF, 33mg/mL in Ethanol Storage Store at -20℃, stored under nitrogen
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.3491 mL 11.7454 mL 23.4907 mL
5 mM 0.4698 mL 2.3491 mL 4.6981 mL
10 mM 0.2349 mL 1.1745 mL 2.3491 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 35 reference(s) in Google Scholar.)

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