>>Signaling Pathways>> Cardiovascular>>Cadherin Peptide, avian

Cadherin Peptide, avian (Synonyms: H2N-Leu-Arg-Ala-His-Ala-Val-Asp-Val-Asn-Gly-amide )

Catalog No.GP10127

Role in cell adhesion

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Cadherin Peptide, avian Chemical Structure

Cas No.: 127650-08-2

Size 가격 재고 수량
1mg
US$32.00
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5mg
US$105.00
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10mg
US$170.00
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25mg
US$245.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Cadherin Peptide, avian, (C44H75N17O13), a peptide with the sequence Leu-Arg-Ala-His-Ala-Val-Asp-Val-Asn-Gly-NH2, MW= 1050.2. Cadherins (named for "calcium-dependent adhesion") are a class of type-1 transmembrane proteins. They play important roles in cell adhesion, ensuring that cells within tissues are bound together. They are dependent on calcium (Ca2+) ions to function. Cadherins are synthesized as polypeptides and undergo many post-translational modifications to become the proteins which mediate cell-cell adhesion and recognition. Cadherins behave as both receptors and ligands. During development, their behavior assists in properly positioning cells - they are responsible for the separation of the different tissue layers, and for cellular migration. In the very early stages of development, E-cadherin (epithelial cadherin) is most greatly expressed. During the next stage, the development of the neuronal plate, N-cadherin (neural cadherin) is expressed and there is a decrease in E-cadherin. Finally, during the development of the notochord and the condensation of somites, E- P- and N-cadherin expression increases. After development, cadherins play a role in maintaining cell and tissue structure, and in cellular movement.

References:
1. Harris, Tony J.C., and Ulrich Tepass. "Adherins Junctions: From Molecules to Morphogenesis" Nature Reviews Molecular Cell Biology. 502-514. July 2010
2. Tepass, Ulrich, et al. "Cadherins in Embryonic and Neural Morphogenisis" Nature Reviews Molecular Cell Biology. November 2000.
3. Tepass, Ulrich, et al. "Cadherins in Embryonic and Neural Morphogenisis" Nature Reviews Molecular Cell Biology. November 2000.

Chemical Properties

Cas No. 127650-08-2 SDF
Synonyms H2N-Leu-Arg-Ala-His-Ala-Val-Asp-Val-Asn-Gly-amide
Chemical Name Cadherin Peptide, avian
Canonical SMILES CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(C)C(=O)NC(CC1=CN=CN1)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(CC(=O)O)C(=O)NC(C(C)C)C(=O)NC(CC(=O)N)C(=O)NCC(=O)N)N
Formula C44H75N17O13 M.Wt 1050.17
Solubility ≥105mg/mL in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 0.9522 mL 4.7611 mL 9.5223 mL
5 mM 0.1904 mL 0.9522 mL 1.9045 mL
10 mM 0.0952 mL 0.4761 mL 0.9522 mL
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리뷰

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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