Carboxylesterase-IN-2 |
| Catalog No.GC65165 |
Carboxylesterase-IN-2(화합물 4u)는 IC50이 10nM 이하인 Carboxylesterase Notum의 강력한 억제제입니다. Notum은 Wnt 활성에 필요한 팔미톨레오일 에스테르의 가수분해를 통해 작용하는 Wnt 신호전달의 음성 조절제입니다. Carboxylesterase-IN-2는 암 질환 연구의 잠재력을 가지고 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2764748-88-9
Sample solution is provided at 25 µL, 10mM.
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Carboxylesterase-IN-2 (compound 4u) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-2 has the potential for the research of cancer disease[1].
[1]. Steadman D, et al. Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity. J Med Chem. 2022;65(1):562-578.
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