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Carboxylesterase-IN-3

Catalog No.GC65167

Carboxylesterase-IN-3(화합물 4y)은 10nM 이하의 IC50을 갖는 Carboxylesterase Notum의 강력한 억제제입니다. Notum은 Wnt 활성에 필요한 팔미톨레오일 에스테르의 가수분해를 통해 작용하는 Wnt 신호전달의 음성 조절제입니다. Carboxylesterase-IN-3는 암 질환 연구에 대한 잠재력이 있습니다.

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Carboxylesterase-IN-3 Chemical Structure

Cas No.: 2764748-92-5

Size 가격 재고 수량
5mg
US$270.00
재고 있음
10mg
US$432.00
재고 있음
25mg
US$855.00
재고 있음
50mg
US$1,305.00
재고 있음

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Carboxylesterase-IN-3 (compound 4y) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-3 has the potential for the research of cancer disease[1].

[1]. Steadman D, et al. Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity. J Med Chem. 2022;65(1):562-578.

Chemical Properties

Cas No. 2764748-92-5 SDF Download SDF
Formula C11H6Cl2N4OS M.Wt 313.16
Solubility Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.1933 mL 15.9663 mL 31.9326 mL
5 mM 0.6387 mL 3.1933 mL 6.3865 mL
10 mM 0.3193 mL 1.5966 mL 3.1933 mL
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리뷰

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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