>>Signaling Pathways>> Others>> Toxicology>>(±)-Cotinine-d3

(±)-Cotinine-d3

Catalog No.GC46284

An internal standard for the quantification of cotinine

Products are for research use only. Not for human use. We do not sell to patients.

(±)-Cotinine-d3 Chemical Structure

Cas No.: 110952-70-0

Size 가격 재고 수량
1 mg
US$47.00
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5 mg
US$228.00
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10 mg
US$432.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(±)-Cotinine-d3 is intended for use as an internal standard for the quantification of cotinine by GC- or LC-MS. Cotinine is an alkaloid found in tobacco and a major metabolite of nicotine .1,2 It is formed by oxidation of nicotine by the cytochrome P450 (CYP) isoform CYP2A6.2

1.StÅlhandske, T.The metabolism of nicotine and cotinine by a mouse liver preparationActa. Physiol. Scand.78(2)236-248(1970) 2.Murphy, S.E., Link, C.A., Jensen, J., et al.A comparison of urinary biomarkers of tobacco and carcinogen exposure in smokersCancer Epidemiology, Biomarkers & Prevention13(10)1617-1623(2004)

Chemical Properties

Cas No. 110952-70-0 SDF
Canonical SMILES O=C(N1C([2H])([2H])[2H])CCC1C2=CC=CN=C2
Formula C10H9D3N2O M.Wt 179.2
Solubility DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 5.5804 mL 27.9018 mL 55.8036 mL
5 mM 1.1161 mL 5.5804 mL 11.1607 mL
10 mM 0.558 mL 2.7902 mL 5.5804 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Review for (±)-Cotinine-d3

Average Rating: 5 ★★★★★ (Based on Reviews and 15 reference(s) in Google Scholar.)

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