>>Signaling Pathways>> Cardiovascular>> Endothelium>>18-Deoxyherboxidiene

18-Deoxyherboxidiene (Synonyms: RQN-18690A)

Catalog No.GC46474

18-Deoxyherboxidene(RQN-18690A)은 강력한 혈관신생 억제제입니다.

Products are for research use only. Not for human use. We do not sell to patients.

18-Deoxyherboxidiene Chemical Structure

Cas No.: 1200128-66-0

Size 가격 재고 수량
500 μg
US$1,198.00
재고 있음
1 mg
US$2,275.00
재고 있음

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

18-Deoxyherboxidiene is a bacterial metabolite that has been found in Streptomyces QN18690 and has antiangiogenic activity.1 It binds to the SF3b subunit of spliceosome-associated protein 130 (SAP130), SAP145, or SAP155 in HeLa cell extracts when used at 100, 1,000, and 10,000 ng and induces the accumulation of unspliced mRNA in HEK293T cells in a reporter assay. 18-Deoxyherboxidiene inhibits VEGF-induced migration of human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner and VEGF-induced HUVEC tube formation when used at a concentration of 0.3 µg/ml.

1.Kakeya, H., Kaida, D., Sekiya, H., et al.RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesisJ. Antibiot. (Tokyo)69(2)121-123(2016)

Chemical Properties

Cas No. 1200128-66-0 SDF
Synonyms RQN-18690A
Canonical SMILES OC(C[C@@H]1O[C@H](/C(C)=C/C=C/[C@H](C[C@@]2([C@@]([C@@H]([C@H](CC)OC)C)(O2)[H])C)C)[C@@H](C)CC1)=O
Formula C25H42O5 M.Wt 422.6
Solubility DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.3663 mL 11.8315 mL 23.663 mL
5 mM 0.4733 mL 2.3663 mL 4.7326 mL
10 mM 0.2366 mL 1.1832 mL 2.3663 mL
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Average Rating: 5 ★★★★★ (Based on Reviews and 3 reference(s) in Google Scholar.)

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