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γ-Lindane

Catalog No.GC48313

An insecticide and GABAA receptor antagonist

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γ-Lindane Chemical Structure

Cas No.: 58-89-9

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100 mg
US$43.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

γ-Lindane is an organochloro insecticide that is an antagonist of GABAA receptors.1 It inhibits GABA-stimulated chloride uptake by membrane vesicles isolated from rat cerebral cortex (IC50 = 68 μM). It binds selectively to insect GABAA receptors over mammalian GABAA receptors in membrane preparations (IC50s = 1, 12, 505, 833, and 150-1, 675 nM for fruit fly, house fly, human, mouse, and rat, respectively).2,3 It binds to a human recombinant β3 homooligomer with similar selectivity as α1β3γ2-containing receptors, indicating that the binding site for γ-lindane on GABAA receptors is located on the β3 subunit (IC50s = 0.90, 21, and 306 nM for β3, α1β3γ2, and the native receptor, respectively).4 γ-Lindane blocks GABA- and glutamate-induced current responses in American cockroach neurons (IC50s = 1.74 and 148 nM, respectively).5 It is toxic to mice and adult house flies (LD50s = 40 and 5.5 mg/kg, respectively) and also kills head lice in vitro and inhibits hatching.4,6

1.Obata, T., Yamamura, H.I., Malatynska, E., et al.Modulation of ?-aminobutyric acid-stimulated chloride influx by bicycloorthocarboxylates, bicyclophosphorus esters, polychlorocycloalkanes and other cage convulsantsJ. Pharmacol. Exp. Ther.244(3)802-806(1988) 2.Hainzl, D., Cole, L.M., and Casida, J.E.Mechanisms for selective toxicity of fipronil insecticide and its sulfone metabolite and desulfinyl photoproductChem. Res. Toxicol.11(12)1529-1535(1998) 3.Llorens, J., SuÑol, C., Tussel, J.M., et al.Lindane inhibition of [35S]TBPS binding to the GABAA receptor in rat brainNeurotoxicol. Teratol.12(6)607-610(1990) 4.Ratra, G.S., Kamita, S.G., and Casida, J.E.Role of human GABAA receptor β3 subunit in insecticide toxicityToxicol. Appl. Pharmacol.172(3)233-240(2001) 5.Ihara, M., Ishida, C., Okuda, H., et al.Differential blocking actions of 4'-ethynyl-4-n-propylbicycloorthobenzoate (EBOB) and ?-hexachlorocyclohexane (?-HCH) on ?-aminobutyric acid- and glutamate-induced responses of American cockroach neuronsInvert. Neurosci.5(3-4)157-164(2005) 6.Meinking, T.L., Taplin, D., Kalter, D.C., et al.Comparative efficacy of treatments for pediculosis capitis infestationsArch. Dermatol.122(3)267-271(1986)

Chemical Properties

Cas No. 58-89-9 SDF
Canonical SMILES Cl[C@@H]1[C@@H](Cl)[C@H](Cl)[C@H](Cl)[C@@H](Cl)[C@@H]1Cl
Formula C6H6Cl6 M.Wt 290.8
Solubility Chloroform: 50 mg/ml,Ethanol: >1 mg/ml,Methanol: >1 mg/ml,Water: 8.35 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.4388 mL 17.1939 mL 34.3879 mL
5 mM 0.6878 mL 3.4388 mL 6.8776 mL
10 mM 0.3439 mL 1.7194 mL 3.4388 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 13 reference(s) in Google Scholar.)

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