>>Signaling Pathways>> Cell Cycle/Checkpoint>> Cytoskeleton & Motor Proteins>>19-O-Acetylchaetoglobosin A

19-O-Acetylchaetoglobosin A (Synonyms: Chaetoglobosin A Acetate)

Catalog No.GC48423

19-O-Acetylchaetoglobosin A는 cytochalasan alkaloid로 C. globosum에서 원래 분리된 곰팡이 대사산물로 액틴 중합 억제 및 세포 독성 활성을 가지고 있습니다. 19-O-아세틸키토글로보신 A는 HeLa 자궁경부암 세포에 세포독성을 나타냅니다.

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19-O-Acetylchaetoglobosin A Chemical Structure

Cas No.: 50939-69-0

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5mg
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Sample solution is provided at 25 µL, 10mM.

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Quality Control & SDS

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Background

19-O-Acetylchaetoglobosin A is a fungal metabolite originally isolated from C. globosum that has actin polymerization inhibitory and cytotoxic activities.1,2 It inhibits actin polymerization in a cell-free assay when used at a concentration of 2 µM.2 19-O-Acetylchaetoglobosin A (3.2, 10, and 32 µg/ml) is cytotoxic to HeLa cervical cancer cells.1

1.Umeda, M., Ohtsubo, K., Saito, M., et al.Cytotoxicity of new cytochalasans from Chaetomium globosumExperientia31(4)435-438(1975) 2.Sekita, S., Yoshihira, K., Natori, S., et al.Structure-activity relationship of thirty-nine cytochalasans observed in the effects on cellular structures and cellular events and on actin polymerization in vitroJ. Pharmacobiodyn.8(11)906-916(1985)

Chemical Properties

Cas No. 50939-69-0 SDF
Synonyms Chaetoglobosin A Acetate
Canonical SMILES [H][C@]1(/C=C/C[C@H](C)/C=C2C)[C@]3([H])O[C@@]3([C@H]([C@]4([C@@H](NC([C@]41C(/C=C/C([C@@H]\2OC(C)=O)=O)=O)=O)CC5=CNC6=C5C=CC=C6)[H])C)C
Formula C34H38N2O6 M.Wt 570.7
Solubility Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.7522 mL 8.7612 mL 17.5223 mL
5 mM 0.3504 mL 1.7522 mL 3.5045 mL
10 mM 0.1752 mL 0.8761 mL 1.7522 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 32 reference(s) in Google Scholar.)

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