>>Signaling Pathways>> Toxins>>α-Conotoxin ImI (trifluoroacetate salt)

α-Conotoxin ImI (trifluoroacetate salt) (Synonyms: α-CTx ImI, GCCSDPRCAWRC)

Catalog No.GC49140

A conotoxin and an antagonist of α7 nAChRs

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α-Conotoxin ImI (trifluoroacetate salt) Chemical Structure

Cas No.: N/A

Size 가격 재고 수량
1 mg
US$83.00
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5 mg
US$315.00
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10 mg
US$546.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

α-Conotoxin ImI is a conotoxin that has been found in C. imperialis and has receptor antagonist and anticancer activities.1 It is a peptide antagonist of homomeric α7 nicotinic acetylcholine receptors (nAChRs; IC50 = 220 nM). α-Conotoxin ImI is selective for α7 nAChRs over α2β2, α3β2, α4β2, α2β4, α3β4, α4β4, and α1β1γδ subunit-containing nAChRs at 5 µM but does inhibit homomeric α9 nAChRs (IC50 = 1,800 nM). Administration of paclitaxel in micelles containing α-conotoxin ImI decreases tumor growth in an MCF-7 mouse xenograft model.2 Intracerebroventricular, but not intraperitoneal, administration of α-conotoxin ImI (20 nmol/animal) induces seizures in rats.3

1.Johnson, D.S., Martinez, J., Elgoyhen, A.B., et al.α-Conotoxin ImI exhibits subtype-specific nicotinic acetylcholine receptor blockade: Preferential inhibition of homomeric α7 and α9 receptorsMol. Pharmacol.48(2)194-199(1995) 2.Mei, D., Lin, Z., Fu, J., et al.The use of α-conotoxin ImI to actualize the targeted delivery of paclitaxel micelles to α7 nAChR-overexpressing breast cancerBiomaterials4252-65(2015) 3.McIntosh, J.M., Yoshikami, D., Mahe, E., et al.A nicotinic acetylcholine receptor ligand of unique specificity, α-conotoxin ImIJ. Biol. Chem.269(24)16733-16739(1994)

Chemical Properties

Cas No. N/A SDF
Synonyms α-CTx ImI, GCCSDPRCAWRC
Canonical SMILES O=C(N[C@H](C(N[C@@H](CSSC[C@@H]1NC([C@H](CSSC[C@@H](NC([C@@H](NC([C@@]2([H])N(CCC2)C([C@@H](NC([C@@H](NC1=O)CO)=O)CC(O)=O)=O)=O)CCCNC(N)=N)=O)C(N[C@H](C(N3)=O)C)=O)NC(CN)=O)=O)C(N)=O)=O)CCCNC(N)=N)[C@@H]3CC4=CNC5=CC=CC=C45.FC(F)(C(O)=O)F
Formula C52H78N20O15S4·XCF3COOH M.Wt 1351.6
Solubility Water: soluble Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 0.7399 mL 3.6993 mL 7.3986 mL
5 mM 0.148 mL 0.7399 mL 1.4797 mL
10 mM 0.074 mL 0.3699 mL 0.7399 mL
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리뷰

Review for α-Conotoxin ImI (trifluoroacetate salt)

Average Rating: 5 ★★★★★ (Based on Reviews and 40 reference(s) in Google Scholar.)

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