>>Signaling Pathways>> PI3K/Akt/mTOR Signaling>> GSK-3>>CHIR98024

CHIR98024 (Synonyms: CT 98024)

Catalog No.GC49392

CHIR98024(화합물 L)는 0.2566μM의 EC50을 갖는 글리코겐 합성효소 키나제 3(GSK3) 억제제입니다.

Products are for research use only. Not for human use. We do not sell to patients.

CHIR98024 Chemical Structure

Cas No.: 556813-39-9

Size 가격 재고 수량
1 mg
US$30.00
재고 있음
5 mg
US$96.00
재고 있음
10 mg
US$176.00
재고 있음
25 mg
US$352.00
재고 있음

Tel:(909) 407-4943 Email: sales@glpbio.com

고객 리뷰

Based on customer reviews.

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

CHIR98024 is an inhibitor of glycogen synthase kinase 3 (GSK3; IC50 = 0.56 nM).1

1.Wagman, A.S., Johnson, K.W., and Bussiere, D.E.Discovery and development of GSK3 inhibitors for the treatment of type 2 diabetesCurr. Pharm. Des.10(10)1105-1137(2004)

Chemical Properties

Cas No. 556813-39-9 SDF
Synonyms CT 98024
Canonical SMILES NC1=NC(NCCNC2=NC=C(C3=NC=CN3)C(C4=C(Cl)C=C(Cl)C=C4)=N2)=CC=C1[N+]([O-])=O
Formula C20H17Cl2N9O2 M.Wt 486.3
Solubility DMSO: slightly soluble,Ethanol: slightly soluble Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.0563 mL 10.2817 mL 20.5634 mL
5 mM 0.4113 mL 2.0563 mL 4.1127 mL
10 mM 0.2056 mL 1.0282 mL 2.0563 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

리뷰

Review for CHIR98024

Average Rating: 5 ★★★★★ (Based on Reviews and 27 reference(s) in Google Scholar.)

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