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Capsiate

Catalog No.GC49433

Capsiate는 매운맛이 없는 CH-19 sweet red pepper 품종에서 추출한 capsaicin 유사체로서 TRPV1의 경구 활성 작용제입니다.

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Capsiate Chemical Structure

Cas No.: 205687-01-0

Size 가격 재고 수량
10 mg
US$271.00
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25 mg
US$643.00
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50 mg
US$1,218.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Capsiate is a non-pungent analog of capsaicin that has been found in C. annuum and has diverse biological activities.1,2,3,4 It inhibits Src in, as well as VEGF-induced proliferation of and tube formation by, human umbilical vein endothelial cells (HUVECs) when used at concentrations ranging from 5 to 25 µM.1 Capsiate activates transient receptor potential vanilloid 1 (TRPV1) in HEK293 cells expressing the human channel (EC50 = 290 nM) and induces licking and biting behaviors, markers of nociception, in mice.2 Topical application of capsiate reduces antigen-induced increases in ear thickness in a mouse model of passive cutaneous anaphylaxis and decreases epidermal thickness and eosinophil and mast cell infiltration in a mouse model of atopic dermatitis.3 Capsiate (10 mg/kg) decreases body weight gain and perirenal fat weight, as well as increases oxygen consumption, fat oxidation, and carbohydrate oxidation, in a mouse model of ad libitum feeding-induced weight gain.4

1.Pyun, B.-J., Choi, S., Lee, Y., et al.Capsiate, a nonpungent capsaicin-like compound, inhibits angiogenesis and vascular permeability via a direct inhibition of Src kinase activityCancer Res.68(1)227-235(2008) 2.Iida, Y., Kobata, T.M., Morita, A., et al.TRPV1 activation and induction of nociceptive response by a non-pungent capsaicin-like compound, capsiateNeuropharmacology44(7)958-967(2003) 3.Lee, J.J., Lee, Y.S., Lee, E.-J., et al.Capsiate inhibits DNFB-induced atopic dermatitis in NC/Nga mice through mast cell and CD4+ T-cell inactivationJ. Invest. Dermatol.135(8)1977-1985(2015) 4.Haramizu, S., Kawabata, F., Ohnuki, K., et al.Capsiate, a non-pungent capsaicin analog, reduces body fat without weight rebound like swimming exercise in miceBiomed. Res.32(4)279-284(2011)

Chemical Properties

Cas No. 205687-01-0 SDF
Canonical SMILES CC(C)/C=C/CCCCC(OCC1=CC(OC)=C(C=C1)O)=O
Formula C18H26O4 M.Wt 306.4
Solubility DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.2637 mL 16.3185 mL 32.6371 mL
5 mM 0.6527 mL 3.2637 mL 6.5274 mL
10 mM 0.3264 mL 1.6319 mL 3.2637 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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리뷰

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Average Rating: 5 ★★★★★ (Based on Reviews and 31 reference(s) in Google Scholar.)

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