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CAY10730

Catalog No.GC43204

CAY10730 is a turn-on fluorescent probe for the detection of nitroreductase activity, a marker of hypoxia.

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CAY10730 Chemical Structure

Cas No.: 2206677-06-5

Size 가격 재고 수량
5mg
US$170.00
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10mg
US$305.00
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25mg
US$679.00
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50mg
US$1,103.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

CAY10730 is a turn-on fluorescent probe for the detection of nitroreductase activity, a marker of hypoxia. In the presence of nitroreductase, CAY10730 is transformed into a highly fluorescent molecule that displays excitation/emission maxima of 454/520 nm, respectively. It is selective for nitroreductase over a variety of bioanalytes, including glutathione, ascorbic acid, and reactive oxygen species such as H2O2. CAY10730 (1 µM) has been used to detect hypoxia in A549 human lung carcinoma cells.

Chemical Properties

Cas No. 2206677-06-5 SDF
Canonical SMILES COC(C=C1)=CC2=C1C3(C(C=CC=C4)=C4C(O3)=O)C(C=CC(OCC5=CC=C([N+]([O-])=O)C=C5)=C6)=C6O2
Formula C28H19NO7 M.Wt 481.5
Solubility DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 1 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.0768 mL 10.3842 mL 20.7684 mL
5 mM 0.4154 mL 2.0768 mL 4.1537 mL
10 mM 0.2077 mL 1.0384 mL 2.0768 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

리뷰

Review for CAY10730

Average Rating: 5 ★★★★★ (Based on Reviews and 38 reference(s) in Google Scholar.)

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