Crustacean Cardioactive Peptide CCAP |
| Catalog No.GC33690 |
갑각류 Cardioactive Peptide CCAP는 고도로 보존된 아미드화 환형 노나펩티드로 해안 게 Carcinus maenas의 심낭 기관에서 처음 분리되었으며, 여기서 심장 박동을 조절하는 역할을 합니다. 갑각류 Cardioactive Peptide CCAP는 또한 다른 절지동물의 신경 활동을 조절합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 309247-84-5
Sample solution is provided at 25 µL, 10mM.
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Crustacean Cardioactive Peptide (CCAP) is a highly conserved, amidated cyclic nonapeptide, first isolated from the pericardial organs of the shore crab Carcinus maenas, where it has a role in regulating heartbeat; Crustacean Cardioactive Peptide (CCAP) also modulates the neuronal activity in other arthropods.
Ultrabithorax and Abdominal-A are not necessary for specification of the CCAP-interneurons, but are absolutely required to prevent the death by apoptosis of the CCAP-efferent neurons[2].
CCAP, FMRFamide and SALDKNFMRFamide increase the mosquito antennal accessory pulsatile organ (APO) and heart contraction rates, increase hemolymph flow velocity in the antennal space[1].
[1]. Suggs JM, et al. CCAP and FMRFamide-like peptides accelerate the contraction rate of the antennal accessory pulsatile organs (auxiliary hearts) of mosquitoes. J Exp Biol. 2016 Aug 1;219(Pt 15):2388-95. [2]. Moris-Sanz M, et al. The study of the Bithorax-complex genes in patterning CCAP neurons reveals a temporal control of neuronal differentiation by Abd-B. Biol Open. 2015 Aug 14;4(9):1132-42.
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