>>Signaling Pathways>> JAK/STAT Signaling>> STAT>>Delphinidin (chloride)

Delphinidin (chloride) (Synonyms: Ephdine)

Catalog No.GC43406

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Delphinidin (chloride) Chemical Structure

Cas No.: 528-53-0

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1mg
US$52.00
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5mg
US$213.00
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10mg
US$400.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Delphinidin (chloride) is an anthocyanidin, a natural plant pigment which serves as the precursor of certain anthocyanins that provide the blue-red colors of flowers, fruits, and red wine.[1] Delphinidin induces the release of nitric oxide by vascular endothelium, causing vasorelaxation.[2] It also inhibits signaling through epithelial growth factor receptors, suppressing the expression of estrogen receptor α and inducing both apoptosis and autophagy at a dose of 1-40 μM.[3],[4] Delphinidin also inhibits the histone acetyltransferase activities of p300/CBP (IC50 = ~ 30 μM).[5]

Reference:
[1]. Holton, T.A., Brugliera, F., Lester, D.R., et al. Cloning and expression of cytochrome P450 genes controlling flower colour. Nature 366, 276-279 (1993).
[2]. Andriambeloson, E., Magnier, C., Haan-Archipoff, G., et al. Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta. Journal of Nutrition 128, 2324-2333 (1998).
[3]. Ozbay, T., and Nahta, R. Delphinidin inhibits HER2 and Erk1/2 signaling and suppresses growth of HER2-overexpressing and triple negative breast cancer cell lines. Breast Cancer 5, 143-154 (2011).
[4]. Aiyer, H.S., Warri, A.M., Woode, D.R., et al. Influence of berry polyphenols on receptor signaling and cell-death pathways: Implications for breast cancer prevention. Journal of Agricultural and Food Chemistry 1-16 (2012).
[5]. Seong, A.R., Yoo, J.Y., Choi, K.C., et al. Delphinidin, a specific inhibitor of histone acetyltransferase, suppresses inflammatory signaling via prevention of NF-κB acetylation in fibroblast-llike synoviocyte MH7A cells. Biochemical and Biophysical Research Communications 18(1), 581-586 (2011).

Chemical Properties

Cas No. 528-53-0 SDF
Synonyms Ephdine
Chemical Name 3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-1-benzopyrylium, chloride
Canonical SMILES OC1=CC2=C(O)C=C(O)C=C2[O+]=C1C3=CC(O)=C(O)C(O)=C3.[Cl-]
Formula C15H11ClO7 M.Wt 338.7
Solubility 30mg/mL in ethanol or DMSO or DMF Storage -20°C, protect from light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.9525 mL 14.7623 mL 29.5247 mL
5 mM 0.5905 mL 2.9525 mL 5.9049 mL
10 mM 0.2952 mL 1.4762 mL 2.9525 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 32 reference(s) in Google Scholar.)

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