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Disitertide (P144)

Catalog No.GC34060

Disitertide(P144)(P144)는 수용체와의 상호작용을 차단하도록 특별히 설계된 펩티드 변형 성장 인자-베타 1(TGF-β1) 억제제입니다. 디시테르타이드(P144)(P144)는 PI3K 억제제이자 세포자멸사 유도제이기도 합니다.

Products are for research use only. Not for human use. We do not sell to patients.

Disitertide (P144) Chemical Structure

Cas No.: 272105-42-7

Size 가격 재고 수량
1mg
US$79.00
재고 있음
5mg
US$315.00
재고 있음
10mg
US$504.00
재고 있음
25mg
US$1,035.00
재고 있음

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고객 리뷰

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Disitertide is an inhibitor of TGF-β1.

Disitertide (P144) prevents TGF-β1-dependent inhibition of MV1Lu proliferation in vitro and markedly reduces binding of TGF-β1 to its receptors. Disitertide blocks TGF-β1-dependent stimulation of a reporter gene under the control of human α2(I) collagen promoter[1].

Treatment with Disitertide at low doses causes a significant inhibition of HSC activation and a marked reduction in liver fibrosis in a rat model of chronic exposure to CCl4. A dose as low as 70 μg of the 15-mer peptide Disitertide, given to rats (300 g body weight) on alternate days, decreases fibrogenesis significantly during chronic exposure to CCl4[1].

[1]. Ezquerro IJ et al. A synthetic peptide from transforming growth factor beta type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury. Cytokine. 2003 Apr;22(1-2):12-20.

Chemical Properties

Cas No. 272105-42-7 SDF
Canonical SMILES Thr-Ser-Leu-Asp-Ala-Ser-Ile-Ile-Trp-Ala-Met-Met-Gln-Asn
Formula C68H109N17O22S2 M.Wt 1580.82
Solubility DMSO : ≥ 200 mg/mL (126.52 mM);Water : < 0.1 mg/mL (insoluble) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 0.6326 mL 3.1629 mL 6.3258 mL
5 mM 0.1265 mL 0.6326 mL 1.2652 mL
10 mM 0.0633 mL 0.3163 mL 0.6326 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

리뷰

Review for Disitertide (P144)

Average Rating: 5 ★★★★★ (Based on Reviews and 29 reference(s) in Google Scholar.)

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