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Dynarrestin

Catalog No.GC50486

Dynarrestin은 세포질 dynein 1 및 2의 아미노티아졸 억제제입니다. Dynarrestin은 ATP 가수분해에 영향을 미치고 섬모 생성을 방해하지 않으면서 시험관 내에서 dynein 1 구동 미세소관 활주와 세포의 다양한 dynein 1 및 2 의존 과정을 빠르고 가역적으로 억제합니다. Dynarrestin은 신경 전구체와 종양 세포의 고슴도치(Hh) 의존적 증식을 억제합니다.

Products are for research use only. Not for human use. We do not sell to patients.

Dynarrestin Chemical Structure

Cas No.: 2222768-84-3

Size 가격 재고 수량
5 mg
US$95.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Dynein inhibitor. Inhibits hedgehog signaling in vitro (IC50 = 0.22 μM). Exhibits reversible inhibition of cytoplasmic dynein 1-dependent microtubule binding and cytoplasmic dynein 2-dependent intraflagellar transport. Inhibits tumor cell proliferation in a mouse medulloblastoma model.

Höing et al (2018) Dynarrestin, a novel inhibitor or cytoplasmic dynein. Cell Chem.Biol. 25 357 PMID:29396292

Chemical Properties

Cas No. 2222768-84-3 SDF
Canonical SMILES CCOC(C1=C(C2=CC=C(N(CC)CC)C=C2)N=C(S1)NC3=C(C=C(C=C3)F)F)=O
Formula C22H23F2N3O2S M.Wt 431.5
Solubility Soluble in DMSO Storage 4°C, protect from light ,unstable in solution, ready to use.
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.3175 mL 11.5875 mL 23.175 mL
5 mM 0.4635 mL 2.3175 mL 4.635 mL
10 mM 0.2317 mL 1.1587 mL 2.3175 mL
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리뷰

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Average Rating: 5 ★★★★★ (Based on Reviews and 38 reference(s) in Google Scholar.)

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