(E)-Akt inhibitor-IV (Synonyms: (E)-AKTIV) |
| Catalog No.GC62122 |
(E)-Akt 억제제-IV((E)-AKTIV)는 강력한 세포독성을 지닌 PI3K-Akt 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 959841-49-7
Sample solution is provided at 25 µL, 10mM.
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(E)-Akt inhibitor-IV ((E)-AKTIV) is a PI3K-Akt inhibitor, with potent cytotoxic[1].
(E)-Akt inhibitor-IV (compound 7) exhibits average GI20 of 0.04 μM on four cell lines (MDA-MB468 cells, MDA-MB231 cells, MCF7 cells and 184B5 cells)[1].(E)-Akt inhibitor-IV shows little effects on the growth of 184B5 non-cancer cells at the average GI20 doses[1].
[1]. Changkun Hu, et al. A 4-aminoquinoline derivative that markedly sensitizes tumor cell killing by Akt inhibitors with a minimum cytotoxicity to non-cancer cells. Eur J Med Chem. 2010 Feb;45(2):705-9.
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