EAI001 |
| Catalog No.GC66432 |
EAI001은 EGFRL858R/T790M에 대해 IC50 값이 24nM인 강력하고 선택적인 돌연변이 표피 성장 인자 수용체(EGFR) 알로스테릭 억제제입니다. 821d96072c2d58d8970e76f526b0f6b8EAI001은 암 연구에 사용할 수 있습니다.821d96072c2d58d8970e76f526b0f6b8
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 892772-75-7
Sample solution is provided at 25 µL, 10mM.
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EAI001 is a potent, selective mutant epidermal growth factor receptor (EGFR) allosteric inhibitor with an IC50 value of 24 nM for EGFRL858R/T790M. EAI001 can be used for research of cancer[1][2].
EAI001 (50 μM) binds to EGFR T790M/C797S/V948R that lies deep inside the EGFR towards the ATP binding site and C-helix. EAI001 showed inhibitory activity due to hydrophobic interaction with amino acid Ile759, Leu747, Leu788, Leu777 and Met766[1].
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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