>>Signaling Pathways>> Ox Stress Reagents>> Lipid Peroxidation>>(-)-FINO2

(-)-FINO2 Sale

Catalog No.GC45248

(-)-FINO2는 강력한 ferroptosis 유도제입니다. (-)-FINO2는 GPX4 활성을 억제합니다. (-)-FINO2는 제1철을 산화시키는 안정한 산화제이며 다양한 pH 수준에서 안정합니다. (-)-FINO2는 광범위한 지질 과산화를 유발합니다.

Products are for research use only. Not for human use. We do not sell to patients.

(-)-FINO2 Chemical Structure

Cas No.: 869298-31-7

Size 가격 재고 수량
1mg
US$89.00
재고 있음
5mg
US$222.00
재고 있음
10mg
US$352.00
재고 있음
50mg
US$1,331.00
재고 있음

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고객 리뷰

Based on customer reviews.

  • GlpBio Citations

    GlpBio Citations
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(-)-FINO2 is a ferroptosis-inducing peroxide compound that indirectly inhibits glutathione peroxidase 4 (GPX4) and oxidizes iron. It decreases GPX4 activity and protein levels in vitro but does not act as an active site, allosteric, or covalent inhibitor of GPX4 or alter GPX homeostasis. It also oxidizes iron in vitro, leading to degradation of the endoperoxide moiety, but does not affect the protein levels of iron regulatory proteins, such as IRP2, FTL1, or TFR. (-)-FINO2 induces lipid peroxidation of a large subset of the lipidome in HT-1080 cells when used at a concentration of 10 µM and induces ferroptosis in an arachidonic acid lipoxygenase-independent manner. It inhibits cell growth (mean GI50 = 5.8 µM) and induces lethality (mean LC50 = 46 µM) in the NCI-60 panel of cancer cell lines. It is selective for oncogenically transformed BJ-ELR cells over noncancerous BJ-hTERT cells when used at concentrations of 15 and 20 µM. (-)-FINO2 (6 µM) induces oxidative stress, including lipid peroxidation, in RS4;11 B-lymphoblastic leukemia cells. It induces iron-dependent cell death, an effect that can be blocked by pretreatment with the lipophilic antioxidants ferrostatin-1 and liproxstatin-1 , and does not induce markers of apoptosis, necrosis, or autophagy in RS4;11 cells.

Chemical Properties

Cas No. 869298-31-7 SDF
Canonical SMILES CC(C)(C)[C@@H](CC1)CC[C@]21CC(CCO)(C)OO2
Formula C15H28O3 M.Wt 256.4
Solubility 30 mg/ml in DMSO, 30 mg/ml DMF, 30 mg/ml in Ethanol Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.9002 mL 19.5008 mL 39.0016 mL
5 mM 0.78 mL 3.9002 mL 7.8003 mL
10 mM 0.39 mL 1.9501 mL 3.9002 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

리뷰

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Average Rating: 5 ★★★★★ (Based on Reviews and 38 reference(s) in Google Scholar.)

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