Flupyrimin |
| Catalog No.GC64394 |
Flupyrimin (FLP)은 삼불화아세틸의 약효운반체고 곤충 니코틴형 아세틸콜린 수용체 (nAChRs)의 길항제로 작용하는 새로운 살충제이다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1689566-03-7
Sample solution is provided at 25 µL, 10mM.
Flupyrimin (FLP)은 삼불화아세틸의 약효운반체고 곤충 니코틴형 아세틸콜린 수용체 (nAChRs)의 길항제로 작용하는 새로운 살충제이다. nAChRs는 주로 곤충의 중추신경계에서 발현되는 리간드-게이트 이온 채널이고 살충제의 직접적인 표적이다[3]. Flupyrimin은 독특한 생물학적 특성을 가진 교차 내성은 없고 수분 곤충에게 안전한 새로운 니코틴계 살충제이다[4]. Flupyrimin은 인간 혈청 알부민/소 혈청 알부민 (HSA/BSA)의 내재 형광을 완화시킬 수 있다[5]. Flupyrimin은 니코틴계 살충제에 둔감한 벼 해충에 대해 좋은 효능을 보인다[6].
References:
[1] Umetsu N, Shirai Y. Development of novel pesticides in the 21st century[J]. Journal of Pesticide Science, 2020, 45(2): 54-74.
[2] Terajima T, Suzuki T, Horikoshi R, et al. Deciphering the flupyrimin binding surface on the insect nicotinic acetylcholine receptor[J]. Journal of Agricultural and Food Chemistry, 2021, 69(33): 9551-9556.
[3] Yuan X F, Zhong H, Xia Z Y, et al. Integrated transcriptome and 1H NMR-based metabolome to explore the potential mechanism of Spodoptera litura in response to flupyrimin[J]. Pesticide Biochemistry and Physiology, 2024, 205: 106146.
[4] Lu X, Xu H, Zhang X, et al. Design, synthesis and bioactivity of novel low bee-toxicity compounds based on flupyrimin[J]. Molecules, 2022, 27(18): 6133.
[5] Zhao Z, Shi T, Chu Y, et al. Comparison of the interactions of flupyrimin and nitenpyram with serum albumins via multiple analysis methods[J]. Chemosphere, 2022, 289: 133139.
[6] Jeschke P. Status and outlook for acaricide and insecticide discovery[J]. Pest management science, 2021, 77(1): 64-76.
| Cas No. | 1689566-03-7 | SDF | |
| Formula | C13H9ClF3N3O | M.Wt | 315.68 |
| Solubility | DMSO : 250 mg/mL (791.94 mM; Need ultrasonic) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.1678 mL | 15.8388 mL | 31.6776 mL |
| 5 mM | 633.6 μL | 3.1678 mL | 6.3355 mL |
| 10 mM | 316.8 μL | 1.5839 mL | 3.1678 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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