FzM1 (Synonyms: Frizzled M1) |
Catalog No.GC41534 |
FzM1은 Frizzled 수용체 FZD4의 음성 알로스테릭 조절제(NAM)입니다. FzM1은 WNT5A 의존성 WNT 반응성 요소(WRE) 활성을 감소시킵니다(log EC50inh=-6.2). FzM1은 FZD4의 세포내 루프 3(ICL3)에 위치한 알로스테릭 결합 부위에 결합하고 수용체의 구조를 변경하여 궁극적으로 WNT/.-카테닌 캐스케이드를 억제합니다.
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Cas No.: 1680196-54-6
Sample solution is provided at 25 µL, 10mM.
Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. Wnt proteins initiate cell signaling by binding Frizzled (Fz) receptors, a family of G protein-coupled receptors. FzM1 is an allosteric ligand of Fz4. At 10 µM, it inhibits nuclear translocation of β-catenin in U87MG glioma cells treated with lithium chloride, a GSK3 inhibitor that enhances the Wnt canonical signaling pathway. FzM1 impairs the ability of U87MG cells to form neurospheres in culture and stimulates the differentiation of Caco-2 epithelial colorectal adenocarcinoma cells.
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