(R)-CE3F4 |
| Catalog No.GC34988 |
(R)-CE3F4는 IC50이 4.2μM인 cAMP isoform 1(Epac1)에 의해 직접 활성화되는 교환 단백질의 강력하고 선택적인 억제제이며 Epac2(IC50, 44μM)보다 Epac1에 대한 10배 선택성입니다.
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Cas No.: 1593478-56-8
Sample solution is provided at 25 µL, 10mM.
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(R)-CE3F4 is a potent and selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1), with an IC50 of 4.2 μM, with 10-fold selectivity for Epac1 over Epac2 (IC50, 44 μM). (R)-CE3F4 is more potent than racemic CE3F4 and (S)-CE3F4[1].
[1]. Courilleau D, et al. The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1). Biochem Biophys Res Commun. 2013 Oct 25;440(3):443-8.
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