>>Signaling Pathways>> GPCR/G protein>> Glucocorticoid Receptor>>(S)-Mapracorat

(S)-Mapracorat (Synonyms: (S)-ZK-245186; (S)-BOL-303242X)

Catalog No.GC35002

(S)-Mapracorat는 선택적이고 덜 활성인 글루코코르티코이드 수용체 작용제입니다.

Products are for research use only. Not for human use. We do not sell to patients.

(S)-Mapracorat Chemical Structure

Cas No.: 887375-15-7

Size 가격 재고 수량
10mM (in 1mL DMSO)
US$663.00
재고 있음
5mg
US$603.00
재고 있음
10mg
US$881.00
재고 있음

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고객 리뷰

Based on customer reviews.

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(S)-Mapracorat is a selective and less active glucocorticoid receptor agonist.

(S)-Mapracorat concentration dependently inhibited TNFα secretion from activated canine PBMC with IC50 value of approximately 0.2 nM.

Intradermal injection of compound 48/80 (50 μg in 50 μL saline) resulted in a clear wheal and flare reaction over the 60 min observation period. Topical pre-treatment with (S)-Mapracorat (0.1%) leads to significant reduction in the wheal and flare responses compared to vehicle (acetone) treated areas.

[1]. BÄumer W , et al. The selective glucocorticoid receptor agonist mapracorat displays a favourable safety-efficacy ratio for the topical treatment of inflammatory skin diseases in dogs. Vet Dermatol. 2017 Feb; 28(1):46-e11.

Chemical Properties

Cas No. 887375-15-7 SDF
Synonyms (S)-ZK-245186; (S)-BOL-303242X
Canonical SMILES CC(C)(C1=C(OCC2)C2=CC(F)=C1)C[C@](O)(CNC3=C4C=CC(C)=NC4=CC=C3)C(F)(F)F
Formula C25H26F4N2O2 M.Wt 462.48
Solubility DMSO: ≥ 50.6 mg/mL (109.41 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.1623 mL 10.8113 mL 21.6226 mL
5 mM 0.4325 mL 2.1623 mL 4.3245 mL
10 mM 0.2162 mL 1.0811 mL 2.1623 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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리뷰

Review for (S)-Mapracorat

Average Rating: 5 ★★★★★ (Based on Reviews and 31 reference(s) in Google Scholar.)

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