AGN 205728 |
| Catalog No.GC35268 |
AGN 205728은 3 nM/0.6 nM의 Ki/IC95 값을 갖는 강력하고 선택적인 RARγ 길항제입니다. RARα 및 RARβ에 대한 억제 없음.
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Cas No.: 859498-05-8
Sample solution is provided at 25 µL, 10mM.
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AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM; no inhibiton on RARα and RARβ.IC50 value: 3 nM/ 0.6 nM(Ki/IC95)Target: RARγ antagonistMore information can be found in the following patent, Compound 7a.Preparation of disubstituted chalcone oximes having RARγ retinoid receptor antagonist activityBy Tsang, Kwok Yin; Sinha, Santosh; Liu, Xiaoxia; Bhat, Smita; Chandraratna, Roshantha A.From PCT Int. Appl. (2005), WO 2005066115 A2 20050721.
[1]. Tsang, Kwok Yin, et al. Preparation of disubstituted chalcone oximes having RARγ retinoid receptor antagonist activity. Appl. (2005), WO 2005066115 A2 20050721.
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