>>Signaling Pathways>> JAK/STAT Signaling>> STAT>>Arnicolide D

Arnicolide D (Synonyms: ARD)

Catalog No.GC35395

Arnicolide D는 Centipeda minima에서 분리된 sesquiterpene 락톤입니다. Arnicolide D는 세포 주기를 조절하고 caspase 신호 전달 경로를 활성화하며 PI3K/AKT/mTOR 및 STAT3 신호 전달 경로를 억제합니다. Arnicolide D는 농도 및 시간 의존적 방식으로 비인두 암종(NPC) 세포 생존을 억제합니다.

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Arnicolide D Chemical Structure

Cas No.: 34532-68-8

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner[1]. Caspase PI3K Akt mTOR STAT3

[1]. Liu R, et al. Arnicolide D, from the herb Centipeda minima, Is a Therapeutic Candidate against Nasopharyngeal Carcinoma. Molecules. 2019 May 17;24(10).

Chemical Properties

Cas No. 34532-68-8 SDF
Synonyms ARD
Canonical SMILES CC(C(O[C@H]1[C@@]([C@@H]2C)([H])[C@@](OC2=O)([H])C[C@@H](C)[C@@]3([H])[C@]1(C(C=C3)=O)C)=O)=C
Formula C19H24O5 M.Wt 332.39
Solubility Soluble in DMSO Storage 4°C, protect from light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.0085 mL 15.0426 mL 30.0851 mL
5 mM 0.6017 mL 3.0085 mL 6.017 mL
10 mM 0.3009 mL 1.5043 mL 3.0085 mL
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Review for Arnicolide D

Average Rating: 5 ★★★★★ (Based on Reviews and 24 reference(s) in Google Scholar.)

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