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Balsalazide sodium hydrate

Catalog No.GC35466

Balsalazide sodium hydrate는 IL-6/STAT3 경로의 조절을 통해 대장염 관련 발암을 억제할 수 있습니다.

Products are for research use only. Not for human use. We do not sell to patients.

Balsalazide sodium hydrate Chemical Structure

Cas No.: 150399-21-6

Size 가격 재고 수량
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Balsalazide sodium hydrate could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway. STAT3 IL-6

At the endpoint, the protein production of MIP-1β, MCP-1, IL-6, and IL-10 in the colon tissues decrease in concordance with the plasma concentrations of the cytokines. The drug-treated groups reveal lower expression of p-STAT3 compared to the CAC group. In addition, BCL2 decreases and BAX increases markedly in the BSZ+VSL#3 group[1]. Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing prodrug[2].

[1]. Do EJ, et al. Suppression of colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway by balsalazide and VSL#3. J Gastroenterol Hepatol. 2016 Aug;31(8):1453-61. [2]. Kruis W, et al. Low dose balsalazide (1.5 g twice daily) and mesalazine (0.5 g three times daily) maintained remission of ulcerative colitis but high dose balsalazide (3.0 g twice daily) was superior in preventing relapses. Gut, 2001. 49(6): p. 783-789.

Chemical Properties

Cas No. 150399-21-6 SDF
Canonical SMILES [O-]C(CCNC(C1=CC=C(/N=N/C2=CC=C([O-])C(C(O)=O)=C2)C=C1)=O)=O.[Na+].[Na+].O.O
Formula C17H17N3Na2O8 M.Wt 437.31
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.2867 mL 11.4335 mL 22.8671 mL
5 mM 0.4573 mL 2.2867 mL 4.5734 mL
10 mM 0.2287 mL 1.1434 mL 2.2867 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 6 reference(s) in Google Scholar.)

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