Belvarafenib TFA (Synonyms: HM95573 TFA; GDC-5573 TFA; RG6185 TFA) |
| Catalog No.GC35488 |
벨바라페닙 TFA(HM95573 TFA)는 B-RAF, B-RAFv600E 및 C-RAF에 대해 IC50이 각각 56nM, 7nM 및 5nM인 강력한 범 RAF(급속 가속 섬유육종) 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Belvarafenib (TFA) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively[1]. IC50: 56 nM(B-RAF), 7 nM(B-RAFv600E), 5 nM(C-RAF)[1].
Belvarafenib (Example 116) is a potent and pan RAF inhibitor with antineoplastic activity. The IC50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. It also shows high inhibitory activity for FMS, DDR1 and DDR2 kinases, with IC50s of 10 nM, 23 nM and 44 nM, respectively[1].
[1]. WO 2013/100632 A1.
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