DK419 |
| Catalog No.GC35873 |
DK419는 0.19μM의 IC50을 갖는 강력하고 경구 활성인 Wnt/β-카테닌 신호전달 억제제입니다. DK419는 Axin2, β-catenin, c-Myc, Cyclin D1 및 Survivin의 단백질 수준을 감소시키고 pAMPK의 생산을 유도합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2102672-22-8
Sample solution is provided at 25 µL, 10mM.
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DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK[1]. Wnt/β-catenin[1]
[1]. Wang J, et al. Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth. Bioorg Med Chem. 2018 Nov 1;26(20):5435-5442.
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