EGFR mutant-IN-1 |
| Catalog No.GC35965 |
5-메틸피리미도피리돈 유도체인 EGFR 돌연변이체-IN-1은 IC50이 27.5nM인 강력하고 선택적인 EGFRL858R/T790M/C797S 돌연변이체 억제제이지만 EGFRWT(IC50 >1.0μM)에 대해서는 훨씬 덜 강력합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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EGFR mutant-IN-1, a 5-methylpyrimidopyridone derivative, is a potent and selective EGFRL858R/T790M/C797S mutant inhibitor with an IC50 of 27.5 nM, while being a significantly less potent for EGFRWT (IC50 >1.0 μM)[1]. IC50: 27.5 nM (EGFRL858R/T790M/C797S) and >1.0 μM (EGFRWT)[1]
[1]. Shen J, et al. Structure-Based Design of 5-Methylpyrimidopyridone Derivatives as New Wild-Type SparingInhibitors of the Epidermal Growth Factor Receptor Triple Mutant (EGFRL858R/T790M/C797S). J Med Chem. 2019 Aug 8;62(15):7302-7308.
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
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