Pyrazofurin |
| Catalog No.GC37042 |
항종양 활성을 갖는 피리미딘 뉴클레오시드 유사체인 피라조푸린은 우리딘 5'-포스페이트(UMP) 합성 효소를 억제함으로써 세포 증식 및 세포 내 DNA 합성을 억제합니다. 피라조푸린은 3개의 편평 세포 암종(SCC) 세포주 Hep-2, HNSCC-14B 및 HNSCC-14C에서 IC50이 0.06-0.37 μM인 활성, 민감한 오로테이트-포스포리보실트랜스퍼라제 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 30868-30-5
Sample solution is provided at 25 µL, 10mM.
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Pyrazofurin, a pyrimidine nucleoside analogue with antineoplastic activity, inhibits cell proliferation and DNA synthesis in cells by inhibiting uridine 5'-phosphate (UMP) synthase[1]. Pyrazofurin is an active, sensitive orotate-phosphoribosyltransferase inhibitor with IC50s between 0.06-0.37 µM in the three squamous cell carcinoma (SCC) cell lines Hep-2, HNSCC-14B and HNSCC-14C[2].
[1]. Ringer DP, et al. Alteration in de novo pyrimidine biosynthesis during uridine reversal of pyrazofurin-inhibited DNA synthesis. Neuropsychopharmacology. J Biochem Toxicol. 1991 Spring;6(1):19-27. [2]. Peters GJ, et al. Antipyrimidine effects of five different pyrimidine de novo synthesis inhibitors in three head and neck cancer cell lines. Nucleosides Nucleotides Nucleic Acids. 2018;37(6):329-339.
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