2-Methoxycinnamaldehyde |
| Catalog No.GC38318 |
2-Methoxycinnamaldehyde(o-Methoxycinnamaldehyde)는 Cinnamomum cassia의 천연 화합물로 항종양 활성이 있습니다. 2-메톡시신남알데하이드는 미토콘드리아 막 전위(δψm) 손실, 카스파제-3 및 카스파제-9 모두의 활성화에 의해 증식을 억제하고 세포자멸사를 유도합니다. 2-Methoxycinnamaldehyde는 PDGF(혈소판 유래 성장 인자)로 인한 HASMC 이동을 효과적으로 억제합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1504-74-1
Sample solution is provided at 25 µL, 10mM.
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2-Methoxycinnamaldehyde (o-Methoxycinnamaldehyde) is a natural compound of Cinnamomum cassia, with antitumor activity[1][2][3]. 2-Methoxycinnamaldehyde inhibits proliferation and induces apoptosis by mitochondrial membrane potential (δψm) loss, activation of both caspase-3 and caspase-9[2]. 2-Methoxycinnamaldehyde effectively inhibits platelet-derived growth factor (PDGF)-induced HASMC migration[3].
[1]. Wong HY, et al. Cinnamomum verum Component 2-Methoxycinnamaldehyde: A Novel Anticancer Agent with Both Anti-Topoisomerase I and II Activities in Human Lung Adenocarcinoma A549 Cells In Vitro and In Vivo. Phytother Res. 2016 Feb;30(2):331-40. [2]. Liu YH, et al. Cinnamomum verum ingredient 2-methoxycinnamaldehyde: a new antiproliferative drug targeting topoisomerase I and II in human lung squamous cell carcinoma NCI-H520 cells. Eur J Cancer Prev. 2017 Jul;26(4):314-323. [3]. Jin YH, et al. 2-Methoxycinnamaldehyde inhibits the TNF-α-induced proliferation and migration of human aortic smooth muscle cells. Int J Mol Med. 2017 Jan;39(1):191-198.
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