(+)-SHIN1 (Synonyms: RZ2994) |
| Catalog No.GC38443 |
(+)-SHIN1((+)-RZ-2994)은 SHIN1의 활성(+) 거울상 이성질체입니다.
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Cas No.: 2443966-90-1
Sample solution is provided at 25 µL, 10mM.
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(+)-SHIN1 ((+)-RZ-2994) is an active (+) enantiomer of SHIN1[1].
(+)-SHIN1 ((+)-RZ-2994) is potent against cytosolic SHMT1 with an IC50 for blocking growth of less than 50 nM and 870 nM in SHMT2 deletion cells and HCT-116 cells, respectively[1].
[1]. Ducker GS, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409.
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