>>Signaling Pathways>> Cancer Biology>> Tumor Microenvironment>>CAY10736

CAY10736 (Synonyms: Compound 51)

Catalog No.GC45404

 

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CAY10736 Chemical Structure

Cas No.: 2251753-61-2

Size 가격 재고 수량
500μg
US$170.00
재고 있음
1mg
US$305.00
재고 있음

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

CAY10736 is an anticancer compound.1 It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.827-9.89 μM). CAY10736 inhibits migration and epithelial-to-mesenchymal transition (EMT) of A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 2.4 and 1.59 μM, respectively) and increases the production of reactive oxygen species (ROS) in these cells in a concentration-dependent manner. CAY10736 (5 mg/kg) reduces tumor growth in B16/F10 melanoma and Lewis lung carcinoma mouse models and an A375 mouse xenograft model.

References
1. Liu, X., Li, B., Zhang, Z., et al. Synthesis and discovery novel anti-cancer stem cells compounds derived from the natural triterpenoic acids. J. Med. Chem. 61(23), 10814-10833 (2018).

Chemical Properties

Cas No. 2251753-61-2 SDF
Synonyms Compound 51
Canonical SMILES C=C1C(C(C)(C)[C@@](CC[C@]2(C)[C@]3([H])CC=C4[C@@]2(C)CC[C@]5(C(NCCNC(NC6=CC=C(OC)C=C6)=S)=O)[C@@]4([H])CC(C)(C)CC5)([H])[C@]3(C)C1)=O
Formula C41H59N3O3S M.Wt 674
Solubility Chloroform: soluble,Ethanol: soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.4837 mL 7.4184 mL 14.8368 mL
5 mM 0.2967 mL 1.4837 mL 2.9674 mL
10 mM 0.1484 mL 0.7418 mL 1.4837 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 21 reference(s) in Google Scholar.)

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