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Guanfacine

Catalog No.GC14813

Guanfacine은 경구 활성 노르아드레날린성 α2A 작용제이며 α2A 수용체 아형에 대해 높은 선택성을 가지고 있습니다.

Products are for research use only. Not for human use. We do not sell to patients.

Guanfacine Chemical Structure

Cas No.: 29110-47-2

Size 가격 재고 수량
10mg
US$34.00
재고 있음
50mg
US$132.00
재고 있음

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Guanfacine is a selective α2A receptor agonist.Target: α2A ReceptorGuanfacine is a sympatholytic. It is a selective α2A receptor agonist. These receptors are concentrated heavily in the prefrontal cortex and the locus coeruleus, with the potential to improve attention resulting from interaction with receptors in the former. Guanfacine lowers both systolic and diastolic blood pressure by activating the central nervous system α2A norepinephrine autoreceptors, which results in reduced peripheral sympathetic outflow and thus a reduction in peripheral sympathetic tone [1, 2].

References:
[1]. Kolar, D., et al., Treatment of adults with attention-deficit/hyperactivity disorder. Neuropsychiatr Dis Treat, 2008. 4(2): p. 389-403.
[2]. Zwieten, P.v., M. Thoolen, and P. Timmermans, The pharmacology of centrally acting antihypertensive drugs. British journal of clinical pharmacology, 1983. 15(Supplement s4): p. 455S-462S.

Chemical Properties

Cas No. 29110-47-2 SDF
Chemical Name N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide
Canonical SMILES C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl
Formula C9H9Cl2N3O M.Wt 246.09
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 4.0636 mL 20.3178 mL 40.6355 mL
5 mM 0.8127 mL 4.0636 mL 8.1271 mL
10 mM 0.4064 mL 2.0318 mL 4.0636 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 7 reference(s) in Google Scholar.)

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