>>Signaling Pathways>> Neuroscience>> Ophthalmology>>KYL (trifluoroacetate salt)

KYL (trifluoroacetate salt) (Synonyms: KYL Peptide)

Catalog No.GC52328

An EphA4 inhibitor

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KYL (trifluoroacetate salt) Chemical Structure

Size 가격 재고 수량
500 μg
US$151.00
재고 있음
1 mg
US$287.00
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5 mg
US$981.00
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10 mg
US$1,812.00
재고 있음

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

KYL is a 12-amino acid synthetic peptide and an inhibitor of the Eph tyrosine kinase receptor A4 (EphA4; IC50 = 4.22 µM).1 KYL inhibits EphA4-induced growth cone collapse in embryonic chicken retina explants when used at a concentration of 5 µM.2

1.Wu, B., Zhang, Z., Noberini, R., et al.HTS by NMR of combinatorial libraries: A fragment-based approach to ligand discoveryChem. Biol.20(1)19-33(2013) 2.Noberini, R., Koolpe, M., Peddibhotla, S., et al.Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptorsJ. Biol. Chem.283(43)29461-29472(2008)

Chemical Properties

Cas No. SDF Download SDF
Synonyms KYL Peptide
Canonical SMILES O=C(N1[C@@H](CCC1)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)=O)=O)[C@@H](NC([C@H](CC2=CC=C(C=C2)O)NC([C@H]3N(CCC3)C([C@H](CC(C)C)NC([C@@H](NC([C@@H](N)CCCCN)=O)CC4=CC=C(C=C4)O)=O)=O)=O)=O)CC5=CNC6=CC=CC=C56.OC(C(F)(F)F)=O
Formula C74H108N14O17 ? XCF3COOH M.Wt 1465.7
Solubility DMF: 33 mg/ml,DMSO: 14 mg/ml,Ethanol: Slightly soluble,PBS (pH 7.2): 0.30 mg/ml Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 0.6823 mL 3.4113 mL 6.8227 mL
5 mM 0.1365 mL 0.6823 mL 1.3645 mL
10 mM 0.0682 mL 0.3411 mL 0.6823 mL
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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