MDL 72527 dihydrochloride |
| Catalog No.GC10545 |
폴리아민 산화효소 (POA) 억제제
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 93565-01-6
Sample solution is provided at 25 µL, 10mM.
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MDL 72527는 폴리아민 산화효소(PAO) 억제제로, 스페르민 산화효소와 N1-아세틸폴리아민 산화효소를 억제합니다(IC50 값은 각각 6.1 및 0.02 µM입니다). 이 물질은 모노아민산화효소나 D-아미노산 산화 효소를 억제하지 않습니다. MDL 72527는 vitro 및 vivo에서 PAO 종속적인 H2O2 생성을 억제하며, 감염, 암 및 고산소증 등 다양한 모델에서 PAO 활동의 역할을 연구하는 데 사용됩니다.
References:
[1]. Moriya, S.S., Miura, T., Takao, K., et al. Development of irreversible inactivators of spermine oxidase and N1-acetylpolyamine oxidase. Biol. Pharm. Bull. 37(3), 475-480 (2014).
[2]. Chaturvedi, R., Cheng, Y., Asim, M., et al. Induction of polyamine oxidase 1 by Helicobacter pylori causes macrophage apoptosis by hydrogen peroxide release and mitochondrial membrane depolarization. J. Biol. Chem. 279(38), 40161-40173 (2004).
[3]. Goodwin, A.C., Destefano, C.E., Wu, S., et al. Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis. Proc. Natl. Acad. Sci. USA 108(37), 15354-15359 (2011).
[4]. Patel, C.A., Xu, Z., Xing, J., et al. Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy. Biochim Biophys. Acta. 1862(9), 1628-1639 (2016).
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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