Pentagastrin (ICI-50123) (Synonyms: AY 6608, NSC 367746) |
| Catalog No.GC32776 |
펜타가스트린(ICI-50123)(ICI-50123)은 CCKB 및 CCKA에 대해 각각 IC50 값이 11nM 및 1100nM인 강력한 선택적 콜레시스토키닌 B(CCKB) 수용체 길항제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 5534-95-2
Sample solution is provided at 25 µL, 10mM.
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pentagastrin is a synthetic polypeptide that has effects like gastrin when given parenterally,which can cause the secretion and synthesis of salivary proteins.[1]In vivo: WIN55, 212-2, which is a non-selective cannabinoid agonist decreased gastric acid secretion stimulated by pentagastrin (10 mg/kg, i.v.) in anaesthetized rats.[2]The effect of curcumin administered i.g. in a dose of 50 mg/kg on the pentagastrin (250 ?g/kg)-stimulated gastric acid output in rats with chronic gastric fistula. [3]
[1]. Loy F et al. Ultrastructural evidence of a secretory role for melatonin in the human parotid gland.J Physiol Pharmacol, 2015 Dec, 66(6):847-53. [2]. Abdel-Salam O et al. Gastric acid inhibitory and gastric protective effects of Cannabis and cannabinoids. Asian Pac J Trop Med, 2016 May, 9(5):413-9. [3]. Czekaj R et al. Role of curcumin in protection of gastric mucosa against stress-induced gastric mucosal damage. Involvement of hypoacidity, vasoactive mediators and sensory neuropeptides. J Physiol Pharmacol, 2016 Apr, 67(2):261-75.
| Cas No. | 5534-95-2 | SDF | |
| Synonyms | AY 6608, NSC 367746 | ||
| Canonical SMILES | O=C(N[C@@H](CCSC)C(N[C@@H](CC(O)=O)C(N[C@H](C(N)=O)CC1=CC=CC=C1)=O)=O)[C@@H](NC(CCNC(OC(C)(C)C)=O)=O)CC2=CNC3=C2C=CC=C3 | ||
| Formula | C37H49N7O9S | M.Wt | 767.89 |
| Solubility | DMSO : ≥ 34 mg/mL (44.28 mM) | Storage | -20°C, protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.3023 mL | 6.5113 mL | 13.0227 mL |
| 5 mM | 260.5 μL | 1.3023 mL | 2.6045 mL |
| 10 mM | 130.2 μL | 651.1 μL | 1.3023 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 25 reference(s) in Google Scholar.)
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