>>Signaling Pathways>> DNA Damage/DNA Repair>> CDK>>(R)-CR8 trihydrochloride

(R)-CR8 trihydrochloride (Synonyms: CR8, (R)-Isomer trihydrochloride)

Catalog No.GC39281

Roscovitine의 2세대 유사체인 (R)-CR8(CR8) trihydrochloride는 강력한 CDK1/2/5/7/9 억제제입니다.

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(R)-CR8 trihydrochloride Chemical Structure

Cas No.: 1786438-30-9

Size 가격 재고 수량
10mM (in 1mL DMSO)
US$97.00
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5mg
US$81.00
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10mg
US$131.00
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50mg
US$419.00
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100mg
US$671.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(R)-CR8 trihydrochloride (CR8 trihydrochloride), a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 trihydrochloride inhibits CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)-CR8 trihydrochloride induces apoptosis and has neuroprotective effect[1][2].

[1]. Bettayeb K, et al. CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases. Oncogene. 2008 Oct 2;27(44):5797-807. [2]. Kabadi SV, et al. CR8, a novel inhibitor of CDK, limits microglial activation, astrocytosis, neuronal loss, and neurologic dysfunction after experimental traumatic brain injury. J Cereb Blood Flow Metab. 2014 Mar;34(3):502-13.

Chemical Properties

Cas No. 1786438-30-9 SDF
Synonyms CR8, (R)-Isomer trihydrochloride
Canonical SMILES CC[C@@H](NC1=NC(NCC2=CC=C(C3=NC=CC=C3)C=C2)=C4N=CN(C(C)C)C4=N1)CO.Cl.Cl.Cl
Formula C24H32Cl3N7O M.Wt 540.92
Solubility DMSO: 62.5 mg/mL (115.54 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.8487 mL 9.2435 mL 18.487 mL
5 mM 0.3697 mL 1.8487 mL 3.6974 mL
10 mM 0.1849 mL 0.9244 mL 1.8487 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Average Rating: 5 ★★★★★ (Based on Reviews and 38 reference(s) in Google Scholar.)

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