(R)-(-)-JQ1 Enantiomer |
| Catalog No.GC63791 |
(R)-(-)-JQ1 거울상 이성질체는 (+)-JQ1의 입체 이성질체입니다. (+)-JQ1은 두 BRD4 표적 유전자의 발현을 강력하게 감소시키는 반면, (R)-(-)-JQ1 거울상 이성질체는 효과가 없습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1268524-71-5
Sample solution is provided at 25 µL, 10mM.
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(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (R)-(-)-JQ1 Enantiomer has no effect.
(R)-(-)-JQ1 Enantiomer shows no significant interaction with any bromodomain. Besides, (R)-(-)-JQ1 Enantiomer is comparatively inactive in nuclear protein in testis (NUT) midline carcinoma (NMC)[1].
[1]. Filippakopoulos, et al. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73.
[2]. Mahe M, et al. An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers. EMBO Mol Med. 2018 Apr;10(4). pii: e8163.
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)
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