>>Signaling Pathways>> Proteases>> Drug Metabolite>>(R)-(-)-O-Desmethyl Venlafaxine D6

(R)-(-)-O-Desmethyl Venlafaxine D6

Catalog No.GC62737

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(R)-(-)-O-Desmethyl Venlafaxine D6 Chemical Structure

Cas No.: 1062609-96-4

Size 가격 재고 수량
1 mg
US$225.00
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5 mg
US$495.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(R)-(-)-O-Desmethyl Venlafaxine D6 is the deuterium labeled (R)-(-)-O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine[1]. Venlafaxine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class[2].

[1]. Yijin Liu, et al. Development of an enantioselective assay for simultaneous separation of venlafaxine and O-desmethylvenlafaxine by micellar electrokinetic chromatography-tandem mass spectrometry: Application to the analysis of drug-drug interaction. J Chromatogr A. 2015 Nov 13;1420:119-28. [2]. F P Bymaste, et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology. 2001 Dec;25(6):871-80.

Chemical Properties

Cas No. 1062609-96-4 SDF
Formula C16H19D6NO2 M.Wt 269.41
Solubility Storage
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.7118 mL 18.5591 mL 37.1181 mL
5 mM 0.7424 mL 3.7118 mL 7.4236 mL
10 mM 0.3712 mL 1.8559 mL 3.7118 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

리뷰

Review for (R)-(-)-O-Desmethyl Venlafaxine D6

Average Rating: 5 ★★★★★ (Based on Reviews and 7 reference(s) in Google Scholar.)

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