(R)-PS210 |
| Catalog No.GC63802 |
(R)-PS210, PS210의 R 거울상 이성질체(화합물 4h-유토머)는 1.8μM의 AC50 값을 갖는 PDK1의 기질 선택적 알로스테릭 활성제입니다. (R)-PS210은 PDK1의 PIF 결합 포켓을 표적으로 합니다. PIF: 단백질 키나제 C-관련 키나제 2(PRK2)-상호작용 단편.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1410101-89-1
Sample solution is provided at 25 µL, 10mM.
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(R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of PDK1 with an AC50 value of 1.8 μM. (R)-PS210 targets to the PIF-binding pocket of PDK1. PIF: The protein kinase C-related kinase 2 (PRK2)-interacting fragment[1].
(R)-PS210 displays an AC50 value of 1.8 μM towards PDK1 in a Cell-Free Kinase Activity Assay. And the maximum activation of PDK1 compared to DMSO control of (R)-PS210 is 5.5 fold[1].
[1]. Wilhelm A, et al. 2-(3-Oxo-1,3-diphenylpropyl)malonic acids as potent allosteric ligands of the PIF pocket of phosphoinositide-dependent kinase-1: development and prodrug concept.J Med Chem. 2012 Nov 26;55(22):9817-30.
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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