(R)-Trolox |
| Catalog No.GC38720 |
(R)-Trolox는 0.83mM의 Ki 값과 1.88mM의 ID50 값을 갖는 비타민 E 유사체이자 경쟁적인 티로시나제 억제제입니다. (R)-Trolox는 (S) 거울상 이성질체(Ki 값 0.61mM)보다 티로시나제 친화도가 더 강합니다.
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Cas No.: 53101-49-8
Sample solution is provided at 25 µL, 10mM.
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(R)-Trolox is a water soluble vitamin E analogue and a competitive tyrosinase inhibitor with a Ki value of 0.83 mM and a ID50 value of 1.88 mM[1]. The (R)-Trolox has stronger tyrosinase affinity than the (S) enantiomer (Ki value of 0.61 mM)[1].
As compared to the control containing no inhibitor, DMSO suppresses the tyrosinase activity at tested levels, 100 and 200 µL in a total volume of 3.0 mL. The inhibition of DMSO on the mushroom tyrosinase is dosedependent. Additions of DMSO at the two levels in the tyrosinase digests containing (R)-Trolox ((R)-HTCCA) results in further inhibitions of the tyrosinase activity. The influence of the DMSO on the inhibitory effects of (R)-Trolox against the tyrosinase is also dose-dependent[1].
[1]. Yu L. Inhibitory effects of (S)- and (R)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acids on tyrosinase activity. J Agric Food Chem. 2003 Apr 9;51(8):2344-7.
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